Endocrine Abstracts

Background: Little is known about the influence of the Predictive Low Glucose suspend (PLGS) function of Sensor Augmented Pump therapy on ketone production in patients with type 1 diabetes mellitus (T1DM), compared to the Low Glucose Suspend function. To evaluate the effect, we compared the frequency of elevated ketone levels, the duration of insulin infusion suspension, the glycaemic control and patient satisfaction between the two settings.Methodology:...

Objective: Nation-wide reimbursement of intermittently scanned continuous glucose monitoring (isCGM) for people with type 1 diabetes was introduced in Belgium in 2016. We investigated whether diabetes knowledge and health literacy would impact glycemic control after one year of isCGM use.Research design and methods: In this substudy of the FUTURE trial, a prospective observational real-world cohort study in individuals with type 1 diabetes ≥16 year...

Background: Cystic fibrosis (CF) is a genetic disorder in which a dysfunctional cystic fibrosis transmembrane regulator (CFTR) chloride channel can result in multimorbidity, including severe respiratory disease and reduced pancreatic exocrine secretion and diabetes. Recently, CFTR modulator therapy, has emerged with the potential of improving respiratory function and remission of diabetes. The effect of CFTR modulator therapy on pancreatic function in patients without preexist...

Background and Aims: To evaluate whether switching from traditional mealtime insulin analogs to fast-acting insulin aspart (Fiasp) in routine clinical practice is efficacious and safe in adult people with type 1 diabetes (PWD1) using intermittent or real-time continuous glucose monitoring (iCGM or rtCGM).Methods: Data from 438 adult PWD1 (60% men, age 44.6±16.1 years, duration of diabetes 21.5±14.0 years, iCGM/rtCGM: 391/47, injections/pump: 409/29...